منابع مشابه
Epiphany or magi?
The season of the Nobel awards and the ensuing ceremonials is upon us. As the current laureates prepare to graciously stand in line before the crowned heads of Sweden and Norway, it’s an appropriate moment to reflect on what the prize has come to mean, and whether it still serves a useful purpose in today’s world. Although the Nobel Prizes are held in high esteem by the general public the world...
متن کاملMagi
DNA methylation (herein, methylation) is an important, heritable, epigenetic modification that is known to influence gene expression, X-inactivation, and cellular differentiation in higher eukaryotes. Next-generation sequencing (NGS) technologies, such as MethylC-seq, make it feasible to investigate methylomes at the cytosine level and provide unparalleled insight into the role and function of ...
متن کاملMagi-1c
The muscle-specific receptor tyrosine kinase (MuSK) forms part of a receptor complex, activated by nerve-derived agrin, that orchestrates the differentiation of the neuromuscular junction (NMJ). The molecular events linking MuSK activation with postsynaptic differentiation are not fully understood. In an attempt to identify partners and/or effectors of MuSK, cross-linking and immunopurification...
متن کاملBerberine, an epiphany against cancer.
Alkaloids are used in traditional medicine for the treatment of many diseases. These compounds are synthesized in plants as secondary metabolites and have multiple effects on cellular metabolism. Among plant derivatives with biological properties, the isoquinoline quaternary alkaloid berberine possesses a broad range of therapeutic uses against several diseases. In recent years, berberine has b...
متن کاملActive Learning with Oracle Epiphany
We present a theoretical analysis of active learning with more realistic interactions with human oracles. Previous empirical studies have shown oracles abstaining on difficult queries until accumulating enough information to make label decisions. We formalize this phenomenon with an “oracle epiphany model” and analyze active learning query complexity under such oracles for both the realizable a...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2012
ISSN: 1469-221X,1469-3178
DOI: 10.1038/embor.2012.163